2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W037355
    4-Maleimidobutyric acid 57078-98-5 99.86%
    4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    4-Maleimidobutyric acid
  • HY-22391
    tert-Butyl (7-aminoheptyl)carbamate 99733-18-3 ≥98.0%
    tert-Butyl (7-aminoheptyl)carbamate (tert-Butyl 2,8-diaminooctanoate) is a PROTAC linker. tert-Butyl (7-aminoheptyl)carbamate can be used to synthesis CPD-10 (HY-168660).
    tert-Butyl (7-aminoheptyl)carbamate
  • HY-W005828
    9-(Boc-amino)nonanoic acid 173435-78-4 ≥98.0%
    9-(Boc-amino)nonanoic Acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. 9-(Boc-amino)nonanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
    9-(Boc-amino)nonanoic acid
  • HY-140756
    Azido-PEG1-NHS ester 1807530-06-8 99.78%
    Azido-PEG1-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG1-NHS ester
  • HY-140197
    Amino-PEG12-Boc 1383814-00-3 ≥98.0%
    Amino-PEG12-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG12-Boc
  • HY-118764
    Propargyl-PEG2-acid 1859379-85-3 ≥98.0%
    Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG2-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-acid
  • HY-124480
    Tetrazine-Ph-acid 1380500-92-4 98.67%
    Tetrazine-Ph-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-acid
  • HY-23166
    Bis-PEG1-acid 5961-83-1 99.90%
    Bis-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bis-PEG1-acid
  • HY-140585
    N-DBCO-N-bis(PEG2-C2-NHS ester) 2128735-29-3
    N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-DBCO-N-bis(PEG2-C2-NHS ester) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    N-DBCO-N-bis(PEG2-C2-NHS ester)
  • HY-W040165
    Amino-PEG3-C2-acid 784105-33-5 99.94%
    Amino-PEG3-C2-acid is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG3-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG3-C2-acid
  • HY-141373
    Bromo-PEG3-bromide 31255-26-2 98.77%
    Bromo-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromo-PEG3-bromide
  • HY-W018174
    m-PEG3-Amine 74654-07-2 98.91%
    m-PEG3-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG3-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG3-Amine
  • HY-140909
    Biotin-PEG11-Mal 1646619-56-8 98.12%
    Biotin-PEG11-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG11-Mal
  • HY-W034599
    Boc-C14-COOH 843666-27-3 ≥98.0%
    Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-C14-COOH
  • HY-40152
    1-Boc-azetidine-3-yl-methanol 142253-56-3 99.99%
    1-Boc-azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-yl-methanol is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]
    1-Boc-azetidine-3-yl-methanol
  • HY-130481
    Propargyl-PEG4-acid 1415800-32-6
    Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells. Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-acid
  • HY-140004
    Azide-PEG3-Tos 178685-33-1 99.15%
    Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azide-PEG3-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG3-Tos
  • HY-140538
    N-Boc-N-bis(PEG2-acid) 2054339-01-2 99.90%
    N-Boc-N-bis(PEG2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Boc-N-bis(PEG2-acid)
  • HY-140199
    Amino-PEG24-Boc 2170987-96-7
    Amino-PEG24-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG24-Boc
  • HY-140648
    Amine-PEG-amine (MW 5000)
    Amine-PEG-amine (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amine-PEG-amine (MW 5000)
PROTAC Linkers Isoform Comparison

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